Wednesday, July 26, 2006

Research Finds Little Proof on Menopause Treatments (click here)

Almost half of American women seek alternative or complementary treatments for the unpleasant symptoms of menopause. But a systematic review of the evidence has found little proof that any of them work.

Researchers reviewed 70 randomized controlled trials of alternative treatments and found insufficient scientific evidence to support the effectiveness of any of the commonly used remedies: herbs, mind-body techniques, energy therapies using magnets or electrical nerve stimulation, homeopathy, naturopathy or culturally based non-Western medical treatments. The review was published yesterday in The Archives of Internal Medicine.

Most of the studies were of poor quality, but even those judged by the researchers to be “fair” or “good” on a three-point scale most often demonstrated little difference between alternative treatments and placebo. For example, a study that compared 56 patients given a soy drink with 55 who drank a medically inactive liquid found no difference between the groups, although both groups got some symptom relief.

Three of four trials of the herb black cohosh, a common alternative treatment for menopausal symptoms, showed no improvement, but the studies suffered from poor methodology. The fourth, judged “fair” by the researchers, enrolled 304 women, half of whom took black cohosh and the other half a placebo for 12 weeks. Compared with placebo, there was greater improvement in the treatment group as measured by the participants’ own reports. Dr. Anne Nedrow, the lead author of the review, said the study “did show some benefits, but we had to balance it with studies that showed none.”

The scientists examined nine studies of mind-body therapies, treatments that focus on the ways in which emotional, mental, social, spiritual and behavioral factors can affect health. While they varied considerably in quality, none found a significant improvement compared with placebo treatment using stress-management techniques, meditation, relaxation exercises, audiotape relaxation or supportive counseling.

Therapies involving reflexology, bone manipulation and magnetic devices were found to be almost completely useless. In one small study of magnets, the placebo group showed more improvement than the group that received the magnet treatment.

Acupuncture was also ineffective. The reviewers examined four trials; three demonstrated no difference between real and sham procedures. The fourth, judged by the reviewers to be of fair quality, compared standard estrogen therapy, sham acupuncture and electroacupuncture, a variation on the practice in which continuous electrical pulses are delivered through the needles. Only the estrogen group improved.

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