Hayley Gudgin of Sammamish, Wash., got her first migraine in 1991 when she was a 19-year-old nursing student.
"I was convinced I was having a brain hemorrhage," she says. "There was no way anything could be that painful and not be really serious."
She retreated to her bed and woke up feeling better the next day. But it wasn't long until another migraine hit. And another. Taking a pill that combines caffeine with the pain relievers acetaminophen and codeine made life manageable until she got pregnant and had to stop taking her medication. After her son was born, the migraines came back. She started taking the drugs again, but they didn't work and actually made her attacks worse.
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https://www.sciencenews.org/article/migraine-headache-new-drugs-block-brain-chemical?