Tuesday, February 16, 2010

Unmet Needs in Pain Therapeutics | The New York Academy of Sciences

Chronic pain can be inflammatory, neuropathic or mixed in its etiology, but usually involves neuroplastic changes that result in hypersensitivity in the peripheral and/or central nervous system. Expression and functional changes of receptors and ion channels in neurons,and more recently in glial cells, has been the focus of much chronic pain research in recent years, but major challenges continue to exist in understanding and creating validated models for the human diseases. This symposium is intended to address both early clinical applications and validation of new pain mechanisms useful for the discovery of new treatments for chronic pain syndromes, as well as discuss the progress and barriers to developing effective preclinical models of pain, in particular fibromyalgia. The ultimate goal of developing an effective disease-modifying therapy for chronic pain conditions such as fibromyalgia have yet to be discovered, but with the establishment and validation of preclinical models this could become a reality.


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