http://www.observer.com/printpage.asp?iid=13599&ic=Featurebox
Created by Gary B. Rollman, Emeritus Professor of Psychology, University of Western Ontario (In addition to links below, see weekly archives in the right column)
Thursday, October 26, 2006
The Residency Rush: How Today’s Docs Pick Their Fields
http://www.observer.com/printpage.asp?iid=13599&ic=Featurebox
Wednesday, October 25, 2006
Psychoneuroimmunology: What Is It and Can It Help Me?
http://www.pnirs.org/
http://www.cousinspni.org/research.htm
Sunday, October 22, 2006
Gene variation affects pain sensitivity and risk of chronic pain
A new NIH-funded study shows that a specific gene variant in humans affects both sensitivity to short-term (acute) pain in healthy volunteers and the risk of developing chronic pain after one kind of back surgery. Blocking increased activity of this gene after nerve injury or inflammation in animals prevented development of chronic pain.
The gene in this study, GCH1, codes for an enzyme called GTP cyclohydrolase. The study suggests that inhibiting GTP cyclohydrolase activity might help to prevent or treat chronic pain, which affects as many as 50 million people in the United States. Doctors also may be able to screen people for the gene variant to predict their risk of chronic post-surgical pain before they undergo surgery. The results appear in the October 22, 2006, advance online publication of Nature Medicine.*
"This is a completely new pathway that contributes to the development of pain," says Clifford J. Woolf, M.D., of Massachusetts General Hospital and Harvard Medical School in Boston, who led the research. "The study shows that we inherit the extent to which we feel pain, both under normal conditions and after damage to the nervous system."
Dr. Woolf carried out the study in collaboration with Mitchell B. Max, M.D., of the National Institute of Dental and Craniofacial Research (NIDCR) in Bethesda, Maryland, and colleagues at the National Institute on Alcoholism Abuse and Alcoholism (NIAAA) and elsewhere. Dr. Woolf's work was funded by the National Institute of Neurological Disorders and Stroke (NINDS). The research team also received funding from NIDCR, NIAAA, and other organizations.
The researchers originally identified GCH1 by preclinical screening for genes that undergo significant changes in expression after sciatic nerve injury. GCH1 is one of several genes that code for enzymes needed to produce a chemical called tetrahydrobiopterin (BH4). Previous studies have shown that BH4 is an essential ingredient in the process that produces dopamine and several other nerve-signaling chemicals (neurotransmitters). It also plays other important roles in the body. However, this study is the first to show that GCH1 and BH4 play a role in pain.
Living with chronic pain (click here)
Since the wealthy philanthropist suffered a stroke five years ago, the slightest movement triggers a burning, stabbing pain on the left side of his body. Even the touch of clothing against his skin is painful.
Nothing has helped, not the 17 different medications or combinations of drugs, not hypnosis or acupuncture. His stroke damaged a part of the brain called the thalamus, a central processing site for pain, and he endured two operations in Belgium that required opening his skull to place electrodes on top of his brain. They didn't work.
Mr. DeGroote is one of an estimated five million Canadians who suffer from chronic pain, but, unlike most people, he faces no financial obstacles in seeking help. The former owner of the Hamilton Tiger-Cats and the waste-management company Laidlaw has sought out experts around North America and Europe without finding relief.
Hope, he has come to believe, lies in laboratories around the world, in scientists struggling to understand the biology of pain and figure out new ways to subdue it.
He is doing his part, giving $20-million to McMaster University in Hamilton to establish the Michael G. DeGroote Institute for Pain Research and Care, which seeks to find new ways to treat and manage chronic pain.
INTERNATIONAL SOCIETY FOR PANETICS
Friday, October 20, 2006
WebMD - Pain Management: Indie Cooper-Guzman, RN
WebMD Pain Management Health Center - Information on pain medications and treatment options for chronic pain
Suffering: A Sociological Introduction by Iain Wilkinson
The Body: The Complete HIV/AIDS Resource
Use the Web to lower barriers between patients and clinicians.
Demystify HIV/AIDS and its treatment.
Improve patients' quality of life.
Foster community through human connection.
http://www.thebody.com/index.html
Pain Management
http://www.thebody.com/treat/pain.html
Pain.com - A world of information on pain
Internet for health care professionals and consumers who have an
interest in pain and its management.
The Dannemiller Memorial Educational Foundation affirms its
commitment to researching, developing, and providing quality
medical educational and informational content to our users
absolutely free in a quality online format. By providing a variety
of accredited activities for physicians, pharmacists and nurses,
the Dannemiller Memorial Educational Foundation seeks to
foster an environment where health care professionals can grow
in their knowledge and management of pain and its management.
The Dannemiller Memorial Educational Foundation further seeks to
empower pain sufferers and their caregivers with information to
better equip them to work in partnership with their physician to
actively manage their pain.
http://www.pain.com/
Ask The Pain Doctor
http://www.pain.com/sections/consumers/ask_the_dr/
Musculoskeletal Pain Resources for Pain Guidelines
American Pain Society A position statement on pediatric chronic pain Swedish Medical Center Chronic Pain & Prescribing Swedish Pain Center's Guide National Guideline Clearinghouse Manual medicine guidelines for musculoskeletal injuries National Guideline Clearinghouse Guidelines for adult low back pain Morecambe Bay Musculoskeletal Pain Commission Group Musculoskeletal Referral Guidelines Massacheuttes General Hospital services American Pain Society Principles of Analgesic Use in the Treatment of Acute Pain and Cancer Pain American Academy of Pain Mediciney Position and Consensus Statements American Academy of Pain Medicine / American Pain Society The use of opioids for the treatment of chronic pain. A consensus statement Royal College of General Practitioners Recommendatons for the appropriate use of opioids for persistent non-cancer pain International Association for the Study of Pain Task Force on Guidelines for Desirable Characteristics for Pain Treatment Facilities American Pain Society Public Policy Statement on Rights and Responsibilities of Healthcare Professionals in the use of Opioids for the Treatment of Pain American College of Rheumatology Ad Hoc Committee on Clinical Guidelines Guidelines for the Initial Evaluation of the Adult Patient with Acute Musculoskeletal Symptoms American Chronic Pain Association Guidelines for selecting a pain management program Agency for Helath Care Policy & Research Acute Pain Management: Operative or Medical Procedures and Trauma Agency for Helath Care Policy & Research Acute Low Back Problems in Adults |
Thursday, October 19, 2006
Pleasure and pain: Study shows brain's 'pleasure chemical' is involved in response to pain too (click here)
The finding, published in the October 18 issue of the Journal of Neuroscience, may help explain why people are more likely to acquire a drug addiction during times of intense stress in their lives. It may also yield clues to why some, but not other chronic pain patients may be prone to developing addictions to certain pain medications. And, it gives further evidence that vulnerability to drug addiction is a very individual phenomenon – and one that can't be predicted by current knowledge of genetics and physiology.
"It appears from our study that dopamine acts as an interface between stress, pain and emotions, or between physical and emotional events, and that it's activated with both positive and negative stimuli," says senior author Jon-Kar Zubieta, M.D., Ph.D., professor of psychiatry and radiology at the U-M Medical School and a member of the U-M Molecular and Behavioral Neuroscience Institute and U-M Depression Center. "It appears to act as a mechanism that responds to the salience of a stimuli – the importance of it to the individual – and makes it relevant for them to respond to."
Wednesday, October 18, 2006
Patient reviews of TENS units (click here)
Saturday, October 14, 2006
Friday, October 13, 2006
Nurse Ratched's Place
Wednesday, October 11, 2006
AllPsych Online - The Virtual Psychology Classroom
Allen Brain Atlas
Welcome to the Neuroscience Gateway, a comprehensive source for the latest research, news and events in neuroscience and genomics research developed collaboratively by the Allen Institute for Brain Science and Nature Publishing Group. The Allen Brain Atlas is a freely available scientific resource developed by the Allen Institute, which provides maps of the expression of approximately 20,000 genes in the mouse brain. Together, the Neuroscience Gateway and the Allen Brain Atlas are new tools to help researchers navigate neuroscience and genomics research.
The Last Word on the Last Breath - New York Times
Dr. Fins thinks that the focus on D.N.R. orders is in itself misguided.
“D.N.R. is a game plan for the last 15 minutes of your life,” he said. “By planning for those last 15 minutes, we’re distorting priorities. Instead of talking about futility, we should be discussing what has utility, like pain management, comfort, closure. Recasting the discussion has led to turning irresolvable dilemmas into problems that can be addressed.”
Friends for Life: An Emerging Biology of Emotional Healing - New York Times
Research on the link between relationships and physical health has established that people with rich personal networks — who are married, have close family and friends, are active in social and religious groups — recover more quickly from disease and live longer. But now the emerging field of social neuroscience, the study of how people’s brains entrain as they interact, adds a missing piece to that data.
The most significant finding was the discovery of “mirror neurons,” a widely dispersed class of brain cells that operate like neural WiFi. Mirror neurons track the emotional flow, movement and even intentions of the person we are with, and replicate this sensed state in our own brain by stirring in our brain the same areas active in the other person
Monday, October 09, 2006
Friday, October 06, 2006
Pain
About this blog
I’ve been in chronic pain since I was a year old, have paid a huge price for this, and spent the last few years reading widely on the subject. This blog contains my own essays as well as links to other writers who interest me.
http://tonycole.wordpress.com/