Until recently it has been difficult to obtain reliable objective information from normal subjects and patients regarding their subjective pain experience. Relating specific neurophysiologic markers to perceptual changes induced by sensitisation, behavioural or pharmacological mechanisms and identifying their site of action within the CNS has been a major goal for scientists, clinicians and the pharmaceutical industry. With the advent of functional neuroimaging methods, such as functional magnetic resonance imaging (FMRI), positron emission tomography (PET) and electroencephalography (EEG) this has been made feasible.
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