Frontiers in Headache Medicine and Facial Pain is a specialty section of Frontiers in Neurology. The specialty deals with the basic mechanisms underlying primary and secondary headache as well as facial pain; their diagnosis and management; as well as their psychological and social impact. These are exciting times for headache medicine and facial pain. We are at the threshold of an explosion in the understanding, diagnosis and treatment of migraine and other headaches. New drugs and scientific breakthroughs are transforming the practice of headache medicine: triptans have been developed, and now CGRP antagonist and selective 5-HT1F agonists are being developed. New drugs and procedures are being tested and developed for the preventive treatment of migraine. Concomitant with the development of new treatments is the development of the basic sciences of headache, and the renewed dedication of clinicians to headache treatment and teaching. Neuroimaging allows us to look at the brain in pain. Animal models are created that mimic human migraine. Headache research is vast, increasingly interdisciplinary, rapidly expanding, and intellectually challenging. The mission of Frontiers in Headache Medicine and Facial Pain is to bring all relevant specialties together on a single platform. We welcome submissions in the areas of epidemiology, pathohysiology, genetics, molecular biology, functional and structural neuroimaging, diagnosis, treatment and treatment guidelines, neuropsychology, neuromodulation, and other non-pharmacological therapies. Frontiers in Headache Medicine and Facial Pain will also provide a forum for the publication of papers from psychologists, basic researchers and other professionals involved in the management of headache and facial pain.