Saturday, May 12, 2007
Surviving a loved one's chronic pain - A guide for family and friends of pain patients (David Kannerstein, PhD and Sarah M. Whitman, MD, Practical Pain Management, 2007)
into my office and inquired what resources were available
for the family members of patients with pain to help
them understand what their loved ones were going through. He
discussed how his wife was frequently angry at him for not doing
more physically at home while she was at work and how she often
yelled at him. He felt guilty about it, but felt he did as much as
he could tolerate. I was embarrassed to admit that I did not
know of any handouts explicitly directed at spouses, family members,
and other loved ones. After doing some research on the
Internet, I discovered several very helpful publications, specifically
Julie Silver's 2004 book, Chronic Pain and the Family: A New
Guide (Harvard University Press) and the American Chronic Pain
Association family manual, ACPA Family Manual: A Manual for
Families of Persons with Pain, written by Penny Cowen (ACPA,
1998). I also found some helpful articles by Mark Grant, a psychologist
in Australia, especially his "Ten Tips for Communicating
With a Person Suffering From Chronic Pain," which is
available on his website, www.overcomingpain.com. Mark was
kind enough to allow us to summarize his suggestions here. As
well, one of us (Whitman) has a website to help patients cope
with chronic pain, and occasionally discusses family issues on it
(www.howtocopewithpain.org). Much of what is in this handout
is taken from these sources.
Monday, May 07, 2007
Tuesday, May 01, 2007
Lyrica Significantly Reduced Pain and Helped Patients Manage the Symptoms of Fibromyalgia (press release)
Significantly more patients treated with Pfizer's Lyrica reduced their pain by 50 percent or more compared with placebo, according to study results presented today at the American Academy of Neurology annual meeting. Clinically, this outcome would equate to a patient with severe pain reporting a reduction to mild to moderate pain.
Fibromyalgia is one of the most common chronic, widespread pain conditions and is thought to result from neurological changes in how patients perceive pain. Fibromyalgia is usually accompanied by poor sleep, stiffness and fatigue. The pain of fibromyalgia can hamper a patient's ability to work and often results in increased medical costs and disability. There are no medications approved to treat fibromyalgia.
"A growing body of evidence is defining the biology behind fibromyalgia that causes such devastating and constant pain," said Dr. I. Jon Russell, one of the study's authors and associate professor of medicine in the division of clinical immunology and rheumatology and director of the university clinical research center at the University of Texas Health Science Center, San Antonio. "A reduction in pain is critical for people living with this condition. With positive new data and new treatments on the horizon, the outlook for people with fibromyalgia has never been better."
The 14-week placebo-controlled study included 745 patients with fibromyalgia who were randomized to receive Lyrica (300mg, 450mg or 600mg) or placebo daily. Patients were asked to measure their pain on a scale of zero to 10; the baseline score for study participants was 6.7 on this 10-point scale.
The study found that patients receiving 600mg a day of Lyrica reduced their pain by 2.05 on the pain scale; 2.03 for patients taking 450mg a day; 1.75 for patients taking 300mg a day, and 1.04 for patients taking placebo.
Significantly more patients treated with Lyrica reduced their pain by 50 percent or more compared with placebo. Of those patients taking 600mg of Lyrica a day, 30 percent said their pain was cut in half or better; 27 percent of those taking 450mg a day and 24 percent of those taking 300mg also reported this level of pain relief. Of those taking placebo, 15 percent reported pain reduction of 50 percent or greater.
Patients receiving Lyrica also reported significant improvements in overall health status and outcomes, including measures such as physical function and ability to perform everyday tasks.
The most common side effects in the study were dizziness and somnolence, followed by weight gain, headache and peripheral edema.http://www.genengnews.com/news/bnitem.aspx?name=16592213
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