This is the most comprehensive overview available anywhere on the broad, multi-faceted and complex topic of pain – and the rapidly evolving scientific and medical disciplines that seek to understand, assess and treat it. More than 3,000 entries provide clear, detailed and up-to-date coverage of the current state of research, and treatment of pain. Essays offer in-depth information on all aspects of nociception and pain, including substrates, causes, pathophysiology, symptoms and signs, diagnoses and treatment. 1,000 color figures enhance understanding. This three-volume reference is an invaluable tool for clinical scientists and practitioners, as well as students, teachers and interested laypersons.